Observer‐based adaptive optimal output containment control problem of linear heterogeneous Multiagent systems with relative output measurements

This paper develops a relative output‐feedback–based solution to the containment control of linear heterogeneous multiagent systems. A distributed optimal control protocol is presented for the followers to not only assure that their outputs fall into the convex hull of the leaders' output but also optimizes their transient performance. The proposed optimal solution is composed of a feedback part, depending of the followers' state, and a feed‐forward part, depending on the convex hull of the leaders' state. To comply with most real‐world applications, the feedback and feed‐forward states are assumed to be unavailable and are estimated using two distributed observers. That is, a distributed observer is designed to measure each agent's states using only its relative output measurements and the information that it receives by its neighbors. Another adaptive distributed observer is designed, which uses exchange of information between followers over a communication network to estimate the convex hull of the leaders' state. The proposed observer relaxes the restrictive requirement of having access to the complete knowledge of the leaders' dynamics by all the followers. An off‐policy reinforcement learning algorithm on an actor‐critic structure is next developed to solve the optimal containment control problem online, using relative output measurements and without requiring the leaders' dynamics. Finally, the theoretical results are verified by numerical simulations.     

Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges

Idiosyncratic drug-induced liver injury (IDILI) remains a significant problem for patients and drug development. The idiosyncratic nature of IDILI makes mechanistic studies difficult, and little is known of its pathogenesis for certain. Circumstantial evidence suggests that most, but not all, IDILI is caused by reactive metabolites of drugs that are bioactivated by cytochromes P450 and other enzymes in the liver. Additionally, there is overwhelming evidence that most IDILI is mediated by the adaptive immune system; one example being the association of IDILI caused by specific drugs with specific human leukocyte antigen (HLA) haplotypes, and this may in part explain the idiosyncratic nature of these reactions. The T cell receptor repertoire likely also contributes to the idiosyncratic nature. Although most of the liver injury is likely mediated by the adaptive immune system, specifically cytotoxic CD8+ T cells, adaptive immune activation first requires an innate immune response to activate antigen presenting cells and produce cytokines required for T cell proliferation. This innate response is likely caused by either a reactive metabolite or some form of cell stress that is clinically silent but not idiosyncratic. If this is true it would make it possible to study the early steps in the immune response that in some patients can lead to IDILI. Other hypotheses have been proposed, such as mitochondrial injury, inhibition of the bile salt export pump, unfolded protein response, and oxidative stress although, in most cases, it is likely that they are also involved in the initiation of an immune response rather than representing a completely separate mechanism. Using the clinical manifestations of liver injury from a number of examples of IDILI-associated drugs, this review aims to summarize and illustrate these mechanistic hypotheses.     

Effects of injection parameters on propagation patterns of hydrogen-fueled rotating detonation waves

Two-dimensional rotating detonation waves (RDWs) with separate injections of hydrogen and air are simulated using the Navier–Stokes equations together with a detailed chemical mechanism. The effects of injection stagnation temperature and slot width on the detonation propagation patterns are investigated. Results find that extremely high temperatures can lead to a chaotic mode in which detonation waves are generated and extinguished randomly. Increasing the slot width can reduce the number of detonation waves and finally trigger detonation quenching at a low injection stagnation temperature. But increasing the slot width can change the RDW propagation pattern from a chaotic to a stable mode under high injection temperature. Furthermore, the kinetic parameter τ (representing the chemical reactivity of the mixture) and the kinematic parameter α (representing the mixing efficiency of hydrogen and oxygen) are introduced to distinguish the RDW propagation patterns.     

基于集员未知输入观测器的风力机桨距执行器故障诊断

风力机一般放置在恶劣的环境中,其桨距执行器极易出现故障。文中针对一类含有未知但有界干扰和噪声的风力机系统的桨距执行器故障问题,设计了集员未知输入观测器对桨距的执行器故障进行检测并分离。采用气动机理和现代辨识原理建立风力机系统模型,通过优化未知输入观测器设计对系统中的干扰解耦,基于中心对称多胞体估计不考虑故障时残差的区间包络,并将其作为残差估计的上下动态阈值,实现状态估计。在上述基础上提出了利用一组集员未知输入观测器进行故障诊断的策略。仿真结果表明,在实验过程中,文中所设计的集员未知输入观测器准确地诊断出了风力机桨距执行器的3阶和5阶线性系统在发生突变故障和缓慢时变故障的时间和位置,证明了所提故障诊断策略的有效性。     

GCAT-U-Net嵌入全局坐标注意力机制的遥感地块分割网络

遥感影像的地块背景特征复杂,当前地块分割方法不能较好地处理模糊的边缘信息,导致分割精度不理想;文章利用注意力机制处理地块特征,提出了一种基于全局坐标注意力机制的遥感地块分割网络:GCAT-U-Net;该方法在U-Net网络基础上嵌入了全局坐标注意力机制,加强了深度神经网络对于遥感影像数据中重要特征的关注度;在公开的GID数据集上的实验结果表明,文章提出的模型将准确率从0.9041提升到了0.9227,比传统U-Net网络提高了2百分点;结合特征自身重要性和特征位置信息的全局坐标注意力机制有助于更精确的目标定位,其输出相较于嵌入单一注意力机制,地块边界更为清晰,提升效果更为显著。     

Distributed-observer-based cooperative control for synchronization of linear discrete-time multi-agent systems

This paper considers output synchronization of discrete-time multi-agent systems with directed communication topologies. The directed communication graph contains a spanning tree and the exosystem as its root. Distributed observer-based consensus protocols are proposed, based on the relative outputs of neighboring agents. A multi-step algorithm is presented to construct the observer-based protocols. In light of the discrete-time algebraic Riccati equation and internal model principle, synchronization problem is completed. At last, numerical simulation is provided to verify the effectiveness of the theoretical results.     

MVVM 设计模式及其应用研究磁

MVVM 即 Model-View-ViewModel ，是微软 WPF 和 Silverlight 应用特有的一种界面设计模式。使用 MVVM设计模式可以帮助我们分离业务逻辑，显示逻辑和用户界面，使得我们的程序代码结构清晰，容易被阅读、测试、维护、替换、扩展和改进。论文意在通过逐层分解对 MVVM 及其应用进行研究。     

Distinguishability of interval type-2 fuzzy sets data by analyzing upper and lower membership functions

In this paper, we deal with the problem of classification of interval type-2 fuzzy sets through evaluating their distinguishability. To this end, we exploit a general matching algorithm to compute their similarity measure. The algorithm is based on the aggregation of two core similarity measures applied independently on the upper and lower membership functions of the given pair of interval type-2 fuzzy sets that are to be compared. Based on the proposed matching procedure, we develop an experimental methodology for evaluating the distinguishability of collections of interval type-2 fuzzy sets. Experimental results on evaluating the proposed methodology are carried out in the context of classification by considering interval type-2 fuzzy sets as patterns of suitable classification problem instances. We show that considering only the upper and lower membership functions of interval type-2 fuzzy sets is sufficient to (i) accurately discriminate between them and (ii) judge and quantify their distinguishability.     

Expression of Genes Controlling Unsaturated Fatty Acids Biosynthesis and Oil Deposition in Developing Seeds of Sacha Inchi (Plukenetia volubilis L.)

Sacha inchi (Plukenetia volubilis L., Euphorbiaceae) seed oil is rich in α-linolenic acid, a kind of n-3 fatty acids with many health benefits. To discover the mechanism underlying α-linolenic acid accumulation in sacha inchi seeds, preliminary research on sacha inchi seed development was carried out from one week after fertilization until maturity, focusing on phenology, oil content, and lipid profiles. The results suggested that the development of sacha inchi seeds from pollination to mature seed could be divided into three periods. In addition, investigations on the effect of temperature on sacha inchi seeds showed that total oil content decreased in the cool season, while unsaturated fatty acid and linolenic acid concentrations increased. In parallel, expression profiles of 17 unsaturated fatty acid related genes were characterized during seed development and the relationships between gene expression and lipid/unsaturated fatty acid accumulation were discussed.     

颗粒在椭圆形回转干馏炉内运动分析

通过实验研究颗粒在不同椭圆滚筒内的运动情况,分析了不同填充率、不同转速和不同颗粒粒径对其的影响。由实验得出:颗粒在椭圆不同位置的运动情况并不一致,随着长短轴之比变大,运动趋于平缓;填充率降低会引起颗粒运动模式过渡区间变大,进入小瀑布模式所需转速增加;颗粒粒径增大,颗粒在筒内受重力、摩擦力的影响变得更加明显,在长轴垂直水平位置,所受惯性影响更加显著,并出现明显的多种模式相结合的运动形式。